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indicates that the combination of both drugs, administered in low doses for 30 days to middle-aged men with impaired functional and structural characteristics of arterial walls, leads to an increase in the expression of Sirt1 (1.8 times), telomerase activity, the catalytic subunit of AMP 2 protein kinase (PRKAA) (1.5 times), and the KLOTHO gene (1.7 times) after just 30 days of treatment [132]

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Elevated ROS levels can cause DNA damage, leading to mutations and genomic instability