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Note: Control group (150 min: n = 5

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ROS are generated very early after reperfusion of ischemic tissue, resulting in oxidative stress that is major cause of cellular injury.8 During ischemia, the physiologic form of the Xanthine dehydrogenase is converted to the ROS-producing form Xanthine oxidase.41 On reoxygenation, Xanthine oxidase reacts with molecular oxygen to produce ROS

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10.1016/j.neuron.2015.05.046 Neuron 19 KatzP

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