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53 Phase 1 clinical trials investigated the safety and tolerability of tirzepatide both in healthy people and people with T2DM

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Similarly, liver transcriptome analysis of dairy cows exposed to environmental heat stress (THI: 7482 for 14 days) revealed down regulation of protein-coding genes in mitochondria ( COX1 , COX2 , CYTB , ND1 and ND2 ) and key regulators of phosphorylation and milk fat synthesis ( ASCL1 , KCNIP4 ), while genes involved in immune response ( HAMP , SAA3 and IL1B ) were upregulated compared with cows in thermoneutral conditions (THI: 68) (Li et al., 2023)