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In addition to acting on opioid receptors, opioid peptides have also been shown to interact with toll-like receptors (TLR), particularly TLR4 (Eidson and Murphy 2013

One heavy session can delay soft-tissue healing by 5-7 days based on inflammatory marker recovery times (Koyuncu et al., 2025)

Research on dose-response relationships in regenerative peptides shows bell-shaped curves more often than linear relationships

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