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Developing preventive measures to fight cardiovascular diseases requires understanding how the gut microbiota interacts with the cardiovascular system

A study reported that individuals with heart defects have high levels of endotoxin in the blood with edema and higher levels of proinflammatory components like cytokines than people without edema (Niebauer et al., 1999)

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Effect of PLC on functional parameters and oxidative profile in type 2 diabetes-associated PAD

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However, its metabolic conversion by gut microbiota into TMAO raises significant concerns due to the association of elevated TMAO levels with cardiovascular diseases like atherosclerosis, MI, stroke, and HF