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This mechanism represents a control of the influx of fatty acyl units into mitochondria in response to the intra-mitochondrial acetyl-CoA level, in addition to the finely regulated mechanism of CPT1 by malonyl-CoA

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Secondary carnitine deficiency is more common and is usually associated with dialysis in chronic renal failure, although it can also be induced by intestinal resection, severe infection, and liver disease

doi: 10.1177/29767342251360872 96 BhasinSStorerTWBermanNCallegariCClevengerBPhillipsJet al

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Vincevica-Gaile et al