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* Compared by Fishers exact test

11 Our findings indicate that, when used as a standalone treatment, ALC significantly reduced depressive symptoms compared to placebo or no treatment

A total of 30 male BALB/c nude mice were randomly divided into four groups: a CT26 + 0.9%NaCl group (8 mice bearing CT26 tumors, treated with vehicle, as a control model of cancer cachexia), a 0.9%NaCl group (6 mice without tumors, treated with the vehicle, as normal controls), a CT26 + LC1 group (8 mice with CT26 tumors, treated with1 mg/kg bodyweight L-carnitine) and a CT26 + LC10 group (8 mice with CT26 tumors treated with10 mg/kg bodyweight L-carnitine)

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A drop of a 1% aqueous solution of phosphotungstic acid dye was used to stain the freshly made sample, which was then placed onto the surface of a carbon-coated copper grid for TEM visualization