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Apart from collagen degradation owing to excessive MMP expression, ROS also triggers a decrease in collagen production by inhibiting the TGF- signal pathway (75)
Ulcerative colitis is associated with impaired mucosal barrier function, which allows luminal bacteria to generate a prolonged and uncontrollable inflammatory response
Liu F, Kim J-k, Li Y, Liu X-q, Li J, Chen X
Abstract 15589: Mitochondrial Metabolites Predict Cardiovascular Outcomes and Heart Failure in People With Type 2 Diabetes Mellitus and Vascular Disease: A Tecos Substudy
Tognatta et al., 2020)
Two explanations for this discrepancy are worthy of consideration
