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BioCryst Pharmaceuticals, Inc

Lysosomal cysteine proteases: facts and opportunities

Assuming that these in vitro rate constants reflect the in vivo situation, they indicate that irreversible oxidation would not become a significant factor until very high H 2 O 2 concentrations (1 mM)

Therefore, any pharmacological treatments that can reverse this hyperglutamatergic state hold great promise in the treatment of alcohol, and possibly illicit drug, dependence

At least 7 types of GPXs have been identified (5,6), and their properties will be collected in a table divided into the following types: cytosolic- (cGPX or GPX1), gastrointestinal- (GI-GPX or GPX2), plasma- (pGPX or GPX3), phospholipid hydroperoxide- (PHGPX or GPX4) glutathione peroxidase, GPX5 and GPX6