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Key points The ubiquitinproteasome system (UPS) selectively degrades the majority of the intracellular proteins in an ATP-consuming manner and closely interacts with the autophagosomallysosomal system in physiological and pathophysiological situations

Although the intracellular generation of ROS per se is an inevitable process, cells possess numerous defense systems to counter it

& Cotter, M

In the present study, increased p62 transcriptional levels observed in untreated azoospermia may indicate disrupted autophagy, possibly due to impaired lysosomal degradation, resulting in cellular waste accumulation and increased germ cell loss 43,44,45

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