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In addition, inhibition of SIRT2 led to upregulation of acetylation and expression of P53, exacerbating ferroptosis after CCI

FEBS Lett 580: 48844888, 2006

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Activation of NF-B leads to increased levels of inflammatory cytokines such as IL-1, IL-6, and TNF-, contributing to persistent inflammation in TAO (86, 87)

The same group further reported significant increases in IL-17 from Th17 cells in mice with floxed Gpx4 alleles, suggesting that the proper homeostasis of GSH through Gpx4 specifically is relevant to the homeostasis of multiple T helper cell lineages

doi: 10.1038/35024009