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Injections are far more effective, especially for anyone with an absorption issue like pernicious anemia, Crohns disease, or a history of gastric surgery

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Individuals taking drugs that inhibit gastric acid secretion should consider taking vitamin B 12 in the form of a supplement because gastric acid is not required for its absorption

However, clomiphene also raises estrogen due to its indirect mechanism, potentially causing similar estrogenic side effects as HCG