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5c,d), many of these genes underwent duplication events in the lineage leading to the bobtail squid and prominently in the cephalopod lineage (Fig

Its overexpression in certain cancers and cancer stem cells might be associated with tumor initiation and metastasis, therapy resistance, and epithelial-to-mesenchymal transition (EMT)

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Ferroptosis-inducing combination therapies (e.g., inducers like erastin or RSL3 with temozolomide) also show promise in enhancing conventional treatments (chemotherapy, radiotherapy) and overcoming resistance [12]