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While most people tolerate B12 shots well, it is always best to stay in communication with a qualified medical team

The compound produced measurable weight loss, but not enough to meet the regulatory bar for an obesity drug which requires clinically meaningful weight reduction (typically 5%+ of body weight)

In phase 3 trials, after 56 weeks of treatment, 62% of patients receiving contrave 32 (bupropion SR 360 mg/naltrexone SR 32 mg) lost at least 5% of their body weight as compared to 23% of patients in the placebo group [240]

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Negative side effects may include a paradoxical decrease in energy levels (most likely due to detoxification from methylation) or slight pain at the injection site which diminishes over 5-10 days

In summary, vitamin B12 is essential for many body functions