b12 injection training for non medics Shots at Home: How, Where & How Often to Inject Yourself Are B12 Shots Safe? Royal
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Anderson 2008
At the molecular level, 5-amino-1MQ functions as a competitive inhibitor of NNMT, demonstrating remarkable potency with an IC of 1.2 0.1 M under standard assay conditions (50 M SAM, 100 M nicotinic acid). This represents a dramatic 10-fold improvement over the parent compound 1-methylquinolinium, achieved through strategic amino group substitution that enhances binding affinity to the NNMT active site. The compound's mechanism centers on preventing the methylation of nicotinamide to 1-methylnicotinamide (1-MNA), thereby preserving nicotinamide for recycling back to NAD+ through the salvage pathway. This intervention effectively blocks what researchers have termed the "NNMT metabolic drain" a process that simultaneously depletes NAD+ precursors and consumes cellular methylation capacity
Sufficient amounts of cobalt and copper need to be consumed for this B 12 synthesis to occur
The onset of action varies depending on the individual's condition and severity of deficiency
In people, these bacteria are too far down the digestive tract for the B12 they make to be absorbed
