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The substrates for these reactions are both endogenous (intrinsic) and exogenous (xenobiotics), being mainly electrophiles, Michael acceptors, epoxides, electron-withdrawing structures and carbonyls, which are able to react through nucleophilic additions with GSH

doi: 10.1016/j.ygeno.2023.110601 [DOI] [PubMed] [Google Scholar] 82

Of the 16 glioma patients evaluable over a longer period of time, 25% were without disease progression at the 6-month mark

The main source of energy in most cells is glucose, which enters the cell through specific transporters, particularly glucose transporter 1 (GLUT1) in glial cells (36)

In the similar dose alogliptin decreased malondialdehyde, Nrf2, and glutathione in cyclophosphamide-induced lung toxicity in rats

High Mobility Group Box 1 (HMGB1): Molecular Signaling and Potential Therapeutic Strategies