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By using mice deficient in glutamate-cysteine ligase (GCL) in keratinocytes, the authors found that GSH deficiency results in more DNA damage and cell death, suggesting a crucial role for the antioxidant capacity in skin integrity maintenance [93]

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In SSP, 3-phosphoglycerate (3-PG), the intermediate metabolite of glycolysis, is first converted to 3-phosphohydroxypyruvate (3-PH), which is catalyzed by 3-phosphoglycerate dehydrogenation (PHGDH)

Cell 133(3):462474

Nippon Nogeikagaku Kaishi 1998;72:1537

Erythrocyte free glycine and erythrocyte glutathione-derived glycine were converted to the n -propyl ester heptafluorobutyramide derivatives, and the isotope ratio of each was measured by negative chemical ionization gas chromatographymass spectrometry on an Agilent 6980 gas chromatograph complexed to a 5973 mass spectrometer (Agilent Technologies), monitoring ions at an m/z of 293 to 295