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demonstrated that disc compression in rats produces a long-lasting increase in inflammatory mediators in IVDs and neuropeptides, such as CGRP and growth-associated phosphoprotein 43, in DRGs

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However, the evidence base is almost entirely in-vitro and from a single Russian research group no independent controlled human trials have replicated these findings

Rat calvarial osteoblasts seeded into a scaffold containing the RGD and FHRRIKA sequences were found to remain viable and have higher proliferation kinetics compared to the controls in which no peptides were added [184]