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Testosterone is a vital hormone produced mainly in the testicles in men and, to a lesser extent, in the ovaries in women and the adrenal glands in both sexes

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(2024) confirmed dose-dependent body-weight and fat-mass reduction over a longer treatment window, with improvements in fatty-liver markers

Those with naturally high NNMT activity might respond more dramatically to inhibition, while those with lower baseline activity might see more modest effects

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