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29 A short half-life is often problematic with neuropsychiatric medications because rapid washout can be associated with drug withdrawal symptoms as with benzodiazepines or with drug discontinuation syndromes as with antidepressants

Chen, T.-H

Later Dilley et al

Saitsu Y, Nishide A, Kikushima K, Shimizu K, Ohnuki K

In contrast, recombinant human COX-1 expressed in COS-1 cells yielded 13-HODE and 9-HODE in a 5/1 ratio consuming 10% of the provided LA, while under the same conditions human COX-2 transformed 35% of LA with a 13-HODE/9-HODE ratio of 8/1