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A major challenge in the development of more effective therapeutic strategies for Alzheimers disease is the identification of molecular mechanisms linked to specific pathophysiological features of the disease, explain co-lead authors Mychael Lourenco, PhD, Institute of Medical Biochemistry Leopoldo de Meis, and Carla Nasca, PhD, New York University Grossman School of Medicine, in the journal Molecular Psychiatry

Following attachment to, and extrusion into, the lumen of the ER the signal sequence of the preproinsulin protein is removed