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There is an immense effort to reveal the underlying causes of TDP-43 pathology and the downstream cellular events that are perturbed in diseased neurons

Although medication remains the mainstay of treatment, growing clinical consensus highlights that well-considered dietary choices and nutritional repletion significantly impact both short- and long-term outcomes

doxycycline, venetoclax, oligomycin A, metformin) [104, 106, 107], poly ADP ribose polymerase (PARP) inhibitors [193] and glycolysis inhibitors [194]

Instead, it works to restore homeostatic rhythm baselines

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Drink good coffee , but not too much