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The COX pathway has received the most attention regarding the tight co-localization of PLA 2 enzymes with downstream enzymes within a cell, defined as functional coupling 14 (Figure 2)

Case Studies in Environmental Medicine (Csem)

[DOI] [PMC free article] [PubMed] [Google Scholar] 109.Ribeiro A., Ferraz-de-Paula V., Pinheiro M.L., Vitoretti L.B., Mariano-Souza D.P., Quinteiro-Filho W.M., Akamine A.T., Almeida V.I., Quevedo J., Dal-Pizzol F., et al

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Moreover, enzymes such as lipoxygenases (LOXs) are essential in triggering cell ferroptosis (Shah et al., 2018)

The molecular profile of cerebellar microglia in AD is characterized by increased expression of genes involved in antigen presentation and debris clearance (such as Celf1 , Cd2ap , and Epha1 ) alongside decreased levels of homeostatic genes (such as Clu , Mef2c , and Bin1 ) (Chappell et al., 2018)