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Scientists observed that as organisms age or gain excess weight, their fat cells (adipocytes) produce excessive amounts of NNMT

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Acting as a substance that increases sensitivity to insulin, it improves cells' sensitivity to insulin [21]

[DOI] [PubMed] [Google Scholar] [146].Tobiume K, Matsuzawa A, Takahashi T, Nishitoh H, Morita K, Takeda K, Minowa O, Miyazono K, Noda T, Ichijo H, ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis