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However, these agents may circumvent the irreparable permanent DNA damage by reducing the cellular uptake and metabolic activation of pro-mutagens/pro-carcinogens, inducing the repair pathways and enhancing the detoxification of reactive electrophiles [116]
Additionally, low endosomal pH (~ 45) can break down labile acid PEI to low molecular weight counterparts and reduces the cytotoxicity [73]
10.1073/pnas.1005396107 73 XiaX
These indicate either excessive dosing or sensitivity to the peptide
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