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A study analyzing brain metastases treated with single-fraction SRS (Gamma Knife or Linac-based) followed by surgical resection found that the core and peripheral regions of brain metastases, as well as different SRS modalities, exhibit distinct genomic characteristics, although the association between these mechanisms and clinical outcomes remains unelucidated (104)

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It is a structurally modified analogue with two deliberate pharmaceutical changes

[1] [15] In 2023, it was the 36th most commonly prescribed medication in the United States, with more than 16 million prescriptions