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Several metabolic intermediates, such as long-chain acylcarnitines can cause oxidative stress at high levels and high levels of ROS can then cause damage to cells and tissues, leading to a further decline in performance

Therefore, they become vulnerable to epigenetic dysregulation

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Vitamin B6 contributes to normal energy metabolism

Ann Neurol 37(6):714722 Hart PE, Lodi R, Rajagopalan B, Bradley JL, Crilley JG, Turner C et al (2005) Antioxidant treatment of patients with Friedreich ataxia: four-year follow-up

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