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The clinical potential of this approach is underscored by the approval of istradefylline in Japan and the United States as an adjunct therapy for PD patients experiencing motor fluctuations, representing the most advanced A 2A receptor antagonists in clinical development [480482]

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[41] schizophrenia subgroup findings in MCC (reduced Glu in whole schizophrenia subgroups)

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This enhanced bioavailability makes these injections particularly effective for individuals following reduced-calorie diets