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In the glutathione-associated subnetwork, we observed a key unknown reaction in which the thiol group of glutathione was converted into a hydroxyl group of M292T447 (Fig

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Hyperoxidation can be repaired by sulfiredoxin, but not in human Prdx6 [193]

ACTL6A impacts GSH de novo synthesis mainly by upregulating -glutamyl-cysteine synthesis To further assess the mechanism by which ACTL6A regulates GSH metabolism, we investigated the metabolic fate of U- 13 C glucose by liquid chromatography with mass spectrometry (LCMS), which produces -GC containing two 13 C atoms via GSH de novo synthesis pathway, GSH containing two 13 C atoms via GSH de novo synthesis or the SGOC pathway, or four 13 C atoms via both pathways (Fig

Hacohen, Y
