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With aging, the gradual accumulation of atherosclerotic risk factors, including oxidative stress, inflammation, dyslipidemia, and hyperglycemia, drives metabolic reprogramming in ECs, particularly in regions exposed to disturbed flow with OS, ultimately leading to EC dysfunction and atherosclerosis

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A balanced diet and a healthy lifestyle are important for the proper functioning of the body

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Proton magnetic resonance spectroscopy (1H-MRS) can assess alterations in brain neurochemical profile non-invasively in vivo over time