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doi: 10.1089/ars.2014.5933 29 PupoEPlaAFAvanzatoDMocciaFCruzJETanziFet al

Association of cerebral spinal fluid copper imbalance in amyotrophic lateral sclerosis

Other prescriptions might be for a one-time treatment (e.g., a one-week course of antibiotics)

Although repurposing existing drugs offers a cost-effective and time-efficient alternative for identifying new therapies, their effective concentrationsmeasured as the half-maximal inhibitory concentration (IC50)often exceed the maximum safe plasma levels in humans, creating a major barrier to clinical application

Iwaoka M, Katakura A, Mishima J et al (2015) Mimicking the lipid peroxidation inhibitory activity of phospholipid hydroperoxide glutathione peroxidase (GPx4) by using fatty acid conjugates of a water-soluble selenolane

10.1111/j.1753-4887.2010.00301.x 223 VarshosazJ.JafarianA.SalehiG.ZolfaghariB
