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Toxicol Sci 112:521531 Antoine DJ, Jenkins RE, Dear JW, Williams DP, McGill MR, Sharpe MR, Craig DG, Simpson KJ, Jaeschke H, Park BK (2012) Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

In MS models, reactive astrocytes upregulate P2X 7 receptors, driving cytokine release and oligodendrocyte injury [427, 428]

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In contrast, FGF23 binds to the KlothoFGFR complex and activates the Mitogen-Activated Protein Kinase/Extracellular signal-Regulated Kinase 1 and 2 pathway, leading to the suppression of CYP27B1 and upregulation of the catabolic enzyme 24-hydroxylase (CYP24A1), which accelerates the degradation of 1,25(OH)D (13)

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Beyond CXCL16, additional mechanisms such as low-level CD36 expression, macropinocytotic uptake, and efferocytotic processes may facilitate the clearance of oxidized LDL (114)