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10.1016/0002-9343(79)90066-4 74 FergusonN
Glutathione is synthesized in the cytosol of all cells from their precursor amino acids: glutamic acid, cysteine and glycine by consecutive action of two enzymes: -glutamyl-cysteine (-GluCys) synthetase (also known as glutamate cysteine ligase, GCL) that in a first step uses glutamate and cysteine as a substrate to form the dipeptide -glutamyl-cysteine
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Moreover, the concept of proteostasis resilience, the capacity of cells and tissues to preserve proteome integrity under sustained stress, is emerging as a powerful unifying lens to understand disease vulnerability, progression, and therapeutic responsiveness
Alternatively, Liu et al
The peptide promotes proper wound closure while minimizing complications such as adhesion formation and dehiscence (wound separation)
