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Obesity Drug Trial Produces Disappointing Weight Loss (axokine).The New York Times

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Insulin binding causes autophosphorylation of its receptor, resulting in activation and subsequent tyrosine phosphorylation of insulin receptor substrates and binding of the p85 regulatory subunit of phosphatidyl inositol kinase-3 (PI3K)

J Biol Chem 189:203216 Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E (2012) The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data