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We hypothesize that partial, irreversible receptor desensitization plays a minor role in the development of analgesic tolerance, which is primarily driven by homeostatic adaptations downstream of the receptor that occur when G protein signaling from MOR is not properly titrated by arrestin-3 engagement and the cycle of desensitization and resensitization

2014 M562115) and the Research Initiation Funding of University of South China for the Returned Scholars From Abroad (no

Inflammopharmacol 31 , 573583 (2023)

For example, pre-treatment with a small molecule inhibitor of P300 significantly reduced the level of lactylation in a mouse model of ischemic stroke, helping to maintain neuronal activity and alleviate ischemic brain injury [46]

R.Rodriguez-LarradA.et al (2019)