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Skin pinch: Pinch a fold of skin between the thumb and forefinger

Levels of APP immunostaining provide a gold-standard for clinical identification of diffuse axonal injury both in brain and SCI (Blumbergs et al., 2014), which causes an accumulation of APP, other axonal transport proteins, intracellular components such as lysosomes, neurotrophin, mitochondria and synaptophysin-carrying vesicles

Rub between hands to create a gentle lather

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Mechanism-specific monitoring provides earlier feedback than waiting for global vision changes

& Kollias, G