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These encompass the activation of iron-regulatory proteins, thereby elevating transferrin receptor expression, and the repression of the transcription factor CCAAT/enhancer-binding protein (C/EBP) or bone morphogenetic protein (BMP)-mediated Smad signaling pathways, resulting in attenuated hepcidin expression [779781]

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Research has found that POR and CYB5R1, retained in the endoplasmic reticulum, utilize NADPH to produce ROS, thereby promoting membrane lipid peroxidation [152]

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