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Serious side effects may include allergic reaction

10.1038/bmt.2015.293 182

Limitations and Challenges in Interpreting Findings from Clinical, In Vitro and In Silico Studies The primary impediment to utilizing hesperidin as a compound against SARS-CoV-2 is the disparity between the concentrations of hesperidin utilized in laboratory experiments in vitro and clinical studies (typically three times daily 500 mg per os) and the amounts that can be obtained from consuming citrus fruits

Benefits of the Mediterranean diet-wine association: the role of ingredients

This is a common concern

It is important for people to speak with a healthcare professional before beginning the use of any supplements