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The activation of the forkhead transcription factor DAF-16, which translocates from the cytoplasm to the nucleus upon a broad range of environmental stresses, regulates stress responses, development, and growth 24

To date, 220 non-overlapping QTLs and 254 MTAs have been reported, primarily linked to traits such as LBI, LBS, RRE, RTI, and biomass, which are directly affected by Fe toxicity 31

In pharmacology, this is called therapeutic synergy

doi: 10.1177/019262338701500407

Cell Death & Disease 2023 In vitro studies report glutathione protects cells from oxidative cytotoxicity in part by activating the Nrf2/HO-1 antioxidant-response pathway

Xu H, She P, Ma B, Zhao Z, Li G, Wang Y