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Mechanisms mediating the therapeutic effect of angiogenesis inhibitors Although anti-angiogenic drugs were initially designed to block blood vessel formation, their ability to control tumor growth may be due to several different mechanism, which are not mutually exclusive

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Valenti D, de Bari L, de Rasmo D, Signorile A, Henrion-Caude A, Contestabile A, Vacca RA

They further found that BRD4770 inhibited lipid peroxidation by down-regulating PLO and MDA levels and increasing 4-HNE expression

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