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Physiotherapy Management for Patients with Parkinsons Disease Physical therapy cannot reverse or stop Parkinsons disease

It additionally suppressed receptor of advanced glycation endproducts (RAGE) transcriptional activity via enhanced PPAR functionality and attenuated oxidative stress, thereby abolishing receptor of advanced glycation endproduct (AGE)-mediated stimulation of HSC activation (Lin et al., 2012)

Irisin-loaded bone marrow mesenchymal stem cell-derived exosomes significantly downregulated the expression of Yes-associated protein (YAP), early growth response 1 (EGR1), and ACSL4, inhibited activation of the YAP/EGR1/ACSL4 signaling pathway, significantly increased GSH levels, decreased levels of Fe 2+ , lactate dehydrogenase (LDH), MDA, and lipid ROS, inhibited neuronal ferroptosis and lipid peroxidation, thereby ameliorating oxygen-glucose deprivation and reoxygenation (OGD/R)-induced neuronal injury

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Van Pee et al., 2023)

10.1038/s41380-021-01092-3 102 YangF.FengL.ZhengF.YangF.WuC