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Metabolism and function of coenzyme

Its key role has been confirmed pharmacologically: HIF-1 inhibition significantly reduces the expression of profibrotic mediators and improves pathological progression in pulmonary fibrosis and lung cancer (120122), confirming that HIF-1 is a key regulator of abnormal macrophage activation

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF- activation

Thus, MEM has been reported that in association with sertraline, a selective inhibitor of serotonin reuptake, it shows a suitable efficacy profile in patients with major depression [88, 117119]

Front Pharmacol 15:1328142 Sun D-Y, Hu Y-J, Li X, Peng J, Dai Z-J, Wang S (2025) Unlocking the full potential of memory T cells in adoptive T cell therapy for hematologic malignancies