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The PTC cell lines selected for the in vitro experiments represent some of the most common mutational signatures observed in thyroid cancer, particularly BRAF V600 E is found in more than 60% of PTCs and purports more aggressive tumor phenotype

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Yachechko, R., Pyle, AD., Tshieu, J., Sridharan, R., Clark, AT., Plath, K (2008) Generation of human induced pluripotent stem cells from dermal fibroblasts, PNAS Feb 26, 105(8):2883-2888 Bostick, M., Kim, JK., Esteve, PO, Clark, AT, Pradhan, S and Jacobson, SE (2007) UHRF1 plays a role in maintaining DNA methylation in mammalian cells Science (2007) 317:1760-1764 Dr