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Lab Invest 94(5):503516 Targher G, Corey KE, Byrne CD, Roden M (2021) The complex link between NAFLD and type 2 diabetes mellitusmechanisms and treatments

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Within seconds, neuronal adenosine triphosphate (ATP) depletion triggers a glycolytic surge flooding cells with lactate, destabilizing pH, and paralyzing ion pumps, a biochemical crisis manifesting as cytotoxic edema and acute cognitive-motor dysfunction [16]

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