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Additionally, storage containers and vials should be inspected before use in order to ensure they are free of any cracks or leaks which could potentially affect product contamination

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The loss or mutation of p53 prevents mutant RAS induced cell cycle arrest and senescence, thereby promoting the malignant transformation of these cells [30]

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In other words, B12 deficiency in vegetarians would be due to dietary absence (or insufficient intake in the case of low consumption) and lack of supplementation