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Identification of neutrophil extracellular traps in the blood of patients with systemic inflammatory response syndrome

86 It has been observed in animal models that sustained glucocorticoid stimulation can increase the excitability of glutamatergic neurons and simultaneously decrease the number and plasticity of astrocytes, in addition to decreasing neuronal dendrite connectivity in the hippocampus and frontal cortex, leading to depression

GLP-1 agonists like semaglutide are FDA-approved medications originally developed to treat type 2 diabetes

Unlike sepsis, where treatments are primarily directed against LPS-induced inflammatory responses (e.g., anti-endotoxin antibodies), SAP-induced glycocalyx damage is predominantly driven by pancreatic enzyme activation (e.g., trypsin) and intestinal endotoxin release

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[DOI] [PubMed] [Google Scholar] 60.Bomberger J.M., Parameswaran N., Hall C.S., Aiyar N., Spielman W.S