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So, we recommend using SL vitamin B12 rather than oral and IM, especially in patients who do not tolerate IM injection and patients who need prolonged vitamin B12 supplementation, such as patients with long-term metformin use and patients with pernicious anemia or with gastro-duodenal resection [51,52,53,54]

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Limiting both supports B12s effects

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More recently, the diagnosis has been refined to be more specific to the etiology and location of the pain

Crawford A, Fassett RG, Geraghty DP, Kunde DA, Ball MJ, Robertson IK, et al