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Richter, J

HIF-1 level is regulated through different mechanisms, including its stabilization, phosphorylation, modifications of redox conditions, and interactions with co-activators 43

In addition, G6PD-associated genes were demonstrated to be potentially involved in regulating focal adhesion, the MAPK, Jak-STAT, p53, long-term depression and apoptosis signaling pathways

(1) Classical GPx (GPx1) is reported to be expressed in red blood cells and liver, lung, and kidney tissues and is located in the cytosol, nucleus, and mitochondria