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Shortened or dysfunctional telomeres is one way through which cells from organisms with renewable tissue can permanently withdraw from the cell cycle, other ways can include DNA damage, strong mitogenic signals, and disputed chromatin (Campisi, 2005)

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Studies further indicate that removing potential copper-binding sites on Htt can eliminate coppers pathogenic effect in HD, suggesting that Huntingtons disease is not only a polyglutamine disease but also involves copper-regulated pathogenic mechanisms (131)

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doi: 10.1186/s12974-020-01922-1

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