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The varied success of anti-inflammatory agents suggests that targeting specific inflammatory pathways (like IL-1 or IL-6) or using agents with broad but relevant mechanisms (like colchicine affecting inflammasomes and neutrophil function) may be more effective than general immunosuppression (methotrexate) or targeting single enzymes (darapladib)

Human cytomegalovirus mRNA-1647 vaccine candidate elicits potent and broad neutralization and higher antibody-dependent cellular cytotoxicity responses than the gB/MF59 vaccine

[DOI] [PMC free article] [PubMed] 183.Krikorian R, Shidler MD, Summer SS, Sullivan PG, Duker AP, Isaacson RS, et al

Disruption of this rhythm such as through mild sleep restriction could lead to accumulated oxidative stress and impaired redox clearance in freshly isolated human endothelial cells, providing direct evidence that sleep loss could disrupt the vascular radical balance [257]

Pezzoli, and M

If children are not treated promptly with intravenous glucose, they progress to coma and death [21]